Biomedical Scientist

Résumé du poste

The role involves planning and executing experimental research to identify and validate drugs targeting cancer stem cells and senescent fibroblasts. Responsibilities include performing complex laboratory techniques, maintaining accurate data records, and contributing to manuscript and patent documentation.

Détails du poste

Company Description Chronological ageing is a biological process that results in accumulated cellular damage, ultimately driving the onset of metabolic disfunction. We aim to develop new therapeutic approaches to these ageing-associated diseases, by targeting metabolism in cancer stem cells (CSCs) and senescent fibroblasts. More specifically, we will screen a series of chemical libraries containing FDA-approved drugs, natural products, and novel chemical entities, to identify compounds that can effectively age-associated metabolic features. Through this screening and validation approach, we will identify compounds that preferentially kill CSCs and senescent fibroblasts, using established cell lines. This position will involve the screening and discovery of drugs that target the metabolic phenotype of senescent cells and cancer stem cells, across multiple cancer types. Job Description The purpose of this role is to support Lunella Biotech’s mission in the discovery of anti-ageing and anti-cancer therapeutics. In more detail, you will work as part of a team of scientists, and will be responsible for the co-planning and execution of many experimental aspects of the project. This position will involve the identification and phenotypic validation of drugs that target senescent cells and cancer stem cells. The project will require the use of immunohistochemistry, immunocytochemistry and flow cytometry applied to relevant samples. Responsibilities To perform experiments in the laboratory to test hypotheses regarding ageing and cancer To plan and execute the experiments related to the phenotypic validation of identified drugs targeting CSCs and senescent cells. To apply complex research techniques for the phenotypic validation of drug hits using immunohistochemistry, immunofluorescence and flow cytometry of relevant samples. Take overall responsibility for several experimental components of the project. To maintain accurate records of data and analysis performed of specific experiments for a given project, conducts literature searches, and maintains an up-to-date knowledge of all current experimental methods through professional reading. To demonstrate a willingness to adapt and develop new skills. To write up draft reports for manuscript publication and patent evaluation To present data as required, during lab meetings and conferences To collaborate with members within and outside of the laboratory To comply with Health and Safety regulations To promote equality and diversity and sustain an inclusive and supportive work environment This role detail is a guide to the work you will initially be required to undertake. It may be changed from time to time to meet changing circumstances Qualifications Education Completed Master’s or PhD in related biological/pharmaceutical sciences Publication record in peer-reviewed journals Background & Experience Essential criteria Experience in flow cytometry/FACS analysis Considerable experience of cell culture techniques Experience in fluorescent microscopy Experience in drug screening Experience and a track record in working with and developing a variety of techniques Experience in recording, analyzing and interpreting data Desirable criteria Experience in assays measuring metabolic parameters of cellular models Experience in the co-culture of multiple cell types Experience in proteomics Experience in the generation of stable cell lines using transfection methods Skills & Competencies Proven ability to maintain high experimental reproducibility and reliability to ensure consistent and valid results Ability to work independently within an agreed framework Excellent communication skills on paper and verbally, including good IT skills Ability to work as part of a team Proven ability to follow directions Ability and willingness to learn new analytical methods and skills Good organizational skills Additional information As an equal opportunity employer, Lunella Biotech Inc. is committed to achieving a skilled and diversified workforce that reflects the diversity of the Canadian population. We encourage applications from women, visible minorities, people with disabilities and Aboriginal people. Additional Information As an equal opportunity employer, Lunella Biotech Inc. is committed to achieving a skilled and diversified workforce that reflects the diversity of the Canadian population. We encourage applications from women, visible minorities, people with disabilities and Aboriginal people. Compensation: CAD 65000 - CAD 115000 - yearly

Ce que vous ferez

The role involves planning and executing experimental research to identify and validate drugs targeting cancer stem cells and senescent fibroblasts. Responsibilities include performing complex laboratory techniques, maintaining accurate data records, and contributing to manuscript and patent documentation.

Exigences

Candidates must hold a Master’s or PhD in biological or pharmaceutical sciences and possess a strong publication record. Essential experience includes flow cytometry, cell culture, fluorescent microscopy, and drug screening methodologies.

Compétences indiquées

• Analyse de données · Souhaitée

Autres compétences pertinentes

Relevées dans la description du poste. Confirmez les exigences importantes ci-dessus.

• Flow cytometry
• FACS analysis
• Cell culture
• Fluorescent microscopy
• Drug screening
• Immunohistochemistry
• Immunocytochemistry
• Immunofluorescence
• Data analysis
• Experimental design
• Laboratory techniques
• Scientific writing
• Metabolic assays
• Proteomics
• Transfection
• Cell line generation
• Chemical Libraries
• Fluorescent Microscopy
• Organizational Skills
• Willingness To Learn
• Phenotyping
• Analytical Method
• Planning
• Health and Safety Regulatory Compliance
• Research
• Cell Cultures
• Cell Biology
• Biochemical Assays
• Biotechnology
• Biology
• Biological Process
• Metabolism
• Communication
• Flow Cytometry
• Experimentation
• Fibroblast
• Patents
• Pharmaceutical Sciences

Domaines d’emploi

• Science & Research
• Healthcare
• Engineering
• Biomedical Scientist
• Biologists, Botanists, Zoologists and Related Professionals
• Medical Scientists, Except Epidemiologists